IMMMUNOCYANIN® Sterile is a sterile filteredsolution containing hemocyanin, an oxygen transporter protein, purified from the hemolymph of the mollusk Concholepas concholepas (loco). IMMUNOCYANIN® Sterile has been used with great success by pharmaceutical companies to increase the protection of conventional vaccines in a wide variety of animals.

Biosonda’sadvantageous formulation match with the customer needs witha protein concentration of 200 mg/ml. The formulation of IMMUNOCYANIN® Sterile consists in a sterile solution that preserves the immunogenic and physicochemical properties of the molecule.

Hemocyanins obtained from mollusks, are highly immunogenic in vertebrates, due to their high molecular size (Mr 8.0 x106 to 1.4×107) and their phylogenetic origin, distant from vertebrates. Due to the high molecular weight of hemocyanins, loses its solubility after lyophilization. IMMUNOCYANIN® does not have this disadvantage, because its collection and purification gives rise to a blue, pure and transparent solution. In addition, the hemocyanin from Concholepas concholepas displays  a unique structure consisting in two polypeptide chains, in contrast to the rest of hemocyanins that are made of only one polypeptide chain, thus giving to the molecule more stability and immunogenicity.

Outstanding properties of IMMMUNOCYANIN® Sterile

Conyugation to peptides and haptens:
High-yield conjugation each molecule of CCH contains hundreds of primary amines available for coupling haptens via EDC or NHS ester crosslinkers

Solubility and stability:
Superior solubility, increased solubility compared to KLH allows Blue Carrier Protein to be used in a broader range of conjugation protocols to accommodate unusual or poorly soluble haptens

immunogenicity:
Highly immunogenic—provides essentially the same level of immunogenicity and phylogenetic distance as keyhole limpet hemocyanin (KLH)

immunostimulant:
Increase response when incorporated to antigen preparations, superior protection when incorporated to commercial veterinary vaccines.