in 50% Glycerol
Blue Carrier EDC®
Conjugation Kit
Blue Carrier Protein

Antitumor and Adjuvant Properties

  • Salazar-Onfray F, Pereda C, Reyes D, López MN. TAPCells, the Chilean dendritic cell vaccine against melanoma and prostate cancer. Biol Res. 46:431-40 (2013).
  • Reyes D, Salazar L, Espinoza E, Pereda C, Castellón E, Valdevenito R, Huidobro C, Inés Becker M, Lladser A, López MN, Salazar-Onfray F. Tumourcelllysate-loadeddendriticcellvaccine induces biochemical and memoryimmune response in castration-resistantprostatecancerpatients. Br J Cancer. 109:1488-1497 (2013).
  • Moltedo B., Faunes F., Haussmann D, De Ioannes P, De Ioannes A.E., Puente J, Becker M.I. Immunotherapeutic effect of the Concholepas hemocyanin in the murine bladder cancer model: evidence for conserved anti-tumor properties among hemocyanins. J. Urol. 176: 2690 - 2695 (2006). * Commented by the Editor of J. Urol. Atala A. 176: 2335-2336 (2006).
  • Becker MI, Fuentes A, Del Campo M, Manubens A, Nova E, Oliva H, Faunes F, Valenzuela MA, Campos-Vallette M, Aliaga A, Ferreira J, De Ioannes AE, De Ioannes P, Moltedo B Immunodominant role of CCHA subunit of Concholepas hemocyanin is associated with unique biochemical properties. Int. Immunopharmacol. 9: 330- 339 (2009).

Carrier for peptides and haptens

  • Nakamura S, Yatabe R, Onodera T, Toko K.Sensitive Detection of Capsaicinoids Using a Surface Plasmon Resonance Sensor with Anti-Homovanillic Acid Polyclonal Antibodies. Biosensors (Basel). 3: 374-384 (2013).
  • Grenegard M, Vretenbrant-Öberg K, Nylander M, De´ silets S, Lindström EG, Larsson A, Ramström I, Ramström S, Lindahl TL. The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine. J. Biol. Chem. 283: 18493-18504 (2008).
  • Gravotta D., Deora A., Perret E., Oyanadel C., Soza A., Schreiner R., Gonzalez A., Rodriguez-Boulan, E. AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells. Proc Natl AcadSci U S A. 104: 1564-1569 (2007).
  • Matus S., Burgos, P:V., Bravo-Zehnder M. Kraft R., Porras O.H., Farías P., Barros F., Torrealba F., Massardo L., Jacobelli S., González A. Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis. J. Exper. Med. 204: 3221-3234 (2007).
  • Cancino J., Torrealba C., Soza A., Yuseff M.I., Gravotta D., Henklein P., Rodriguez-Boulan E., Gonzalez A. Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Molecular Biology of the Cell 18: 4872–4884 (2007).
  • Cancino J., Torrealba C., Soza A., Yuseff M.I., Gravotta D., Henklein P., Rodriguez-Boulan E., Gonzalez A. Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Molecular Biology of the Cell 18: 4872–4884 (2007).
  • Jaulin F., Xue X., Rodriguez-Boulan E., Kreitzer E. Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells. Dev. Cell. 13: 457-458 (2007).
  • Corvalán L.A., Araya R., Brañes M.C., Sáez P.J., Kalergis A.M:,Tobar J.A., Theis M., Willecke K., Sáez J.C. Injury of skeletal muscle and specific cytokines induce the expression of gap junction channels in mouse dendritic cells. J. Cell. Physiol. 211: 649 – 660 (2007).
  • Manosalva H., De Ioannes A. E., Becker M.I. Development of monoclonal antibodies bearing the internal image of the gizzerosine epitope and application in a competitive ELISA for fish meal. Hybridoma and Hybridomics 23: 45- 54 (2004).
  • Duvillié B., Attali M., Aiello V., Quemeneur E., RacharfmannR. Label-retaining cells in the rat páncreas. Diabetes 52:2035-2042 (2003).
  • Mura C.V, Becker M. I, Orellana A, Wolf D..Immunopurification of Golgi vesicles by magnetic sorting. J ImmunolMethods. 260: 263-71 (2002).
  • Becker M I, Carrasco, I., Beltrán C., Torres M., Jaureguiberry B., De Ioannes A. E. Development of monoclonal antibodies to Gizerozzine a toxic component present in fish meals. Hybridoma 17: 373-381 (1998).
  • Tan I.P., Roy C., Saez J.C., Saez C.G., Paul D.P. Risley, M.S. Regulated assembly of Connexin33 and Connexin43 into rat Sertoli cell gap junctions. Biol. Reprod. 54: 1300-1310 (1996).
  • Cambiazo V., González M., Maccioni M.B.DMAP-85: A τ-Like Protein from Drosophila melanogaster larvae. J. Neurochem. 64: 1288-1297 (1995).



  • Miller LA, Fagerstone KA, Eckery DC. Twenty years of immunocontraceptive research: lessons learned.J Zoo Wildl Med. 44 (4 Suppl): S84-96 (2013).
  • Pilon J., Loiacono C., Okeson D., Lund S., Vercauteren K., Rhyanc J., Miller L. Anti-prion activity generated by a novel vaccine formulation. Neuroscience Letters 429: 161–164 (2007).
  • Miller L.A., Talwar G.P., Killian G.J. Contraceptive effect of a recombinant GnRH vaccine in adult female pigs. Proc. 22nd Vertebr. Pest. Conf. (R. M. Timm and J. M. O’Brien, Eds.) Published at Univ. of Calif., Davis. Pp. 106-109 (2006).
  • Novel neutralizing immunogen (nimiv) of rhinovirus and its use for vaccine applications field of the invention. (WO/2008/057158 novel neutralizing immunogen (nimiv) of rhinovirus and its use for vaccine applications). WO 2008057158 20080515.
  • Mauldin R.E., Miller L.A. Wildlife contraception: targeting the oocyte. Managing Vertebrate Invasive Species: Proceedings of an International Symposium (G. W. Witmer, W. C. Pitt, K. A. Fagerstone, Eds). USDA/APHIS/WS, National Wildlife Research Center, Fort Collins, CO. (2007).


Biochemical and Immunochemicalproperties

  • Arancibia S, Del Campo M, Nova E, Salazar F, Becker MI. Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects. Eur J Immunol. 42: 688-699. (2012).
  • Manubens A, Salazar F, Haussmann D, Figueroa J, Del Campo M, Pinto JM, Huaquín L, Venegas A, Becker MI.Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism. Cell Tissue Res. 342: 423-435 (2010).
  • Idakieva K., Nikolov P., Chakarska I., Genov N., Shnyrov V.L. Spectroscopic properties and conformational stability of Concholepas concholepashemocyanin. J Fluoresc. DOI 10.1007/s10895-008-0338-x (2008).
  • Leyton p., Lizama-Vergara P.A., Campos-Vallette M., Becker M.I., Clavijo E., Córdova Reyes I., Vera M., Jeréz C.A. Surface enhanced Raman spectrum of nanometric molecular systems. J. Chil. Chem. Soc., 50: 725-730 (2005).
  • De Ioannes P, Moltedo B, Oliva H, Pacheco R, De Ioannes A. E., Becker M.I Hemocyanin of the molluskanConcholepas concholepasexhibits an unusual heterodecameric array of subunits. J. Biological Chemistry 279: 26134-26142 (2004).
  • Oliva, H., Moltedo, B., De Ioannes, P., Faunes, F., De Ioannes, A.E., Becker, M. I. Monoclonal antibodies to molluskanhemocyanin from Concholepas concholepasdemonstrate common and specific epitopes among subunits. Hybridoma and Hybridomics 21: 365 – 374 (2002).
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